Cellular Uptake of Nanoparticles is Regulated by Integrin-Based Adhesion to the Extracellular Matrix.

ABSTRACT: Therapeutic nanoparticle delivery is crucial for a variety of biomedical applications, such as immunizations, gene and drug delivery, tissue engineering, biomedical implant coating, and other regenerative medicine approaches. The uptake of therapeutic nanoparticles occurs through several endocytosis pathways. However, the uptake mechanism of nanoparticles delivered from a substrate is also regulated by cell-substrate interactions and the ability of cells to mechanosense their surrounding extracellular matrix (ECM). These cell-ECM interactions influence integrin signaling, focal adhesion formation, and cytoskeletal rearrangement to impact nanoparticle uptake. In this study, we investigated the role of ECM and ECM-mimetic coatings─collagen I (COL), fibronectin (FN), laminin (LM), hyaluronic

SUBMITTER: Joshi S 

PROVIDER: S-EPMC12867119 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature