5xFAD mutations induce hearing impairment in the Ahl-corrected 5xFAD mice.

ABSTRACT: Age-related hearing impairment (ARHI) has been strongly associated with cognitive impairment in case-controlled and longitudinal population-based studies. However, a mechanistic link between ARHL and Alzheimer's disease (AD)-related dementia remains unclear. In this study, we developed Ahl-corrected C57BL/6-background 5xFAD mice (referred to as FAD2), an AD mouse model suitable for precise assessment of auditory function, along with their wildtype littermates (WT2). WT2 mice of both sexes exhibited stable auditory brainstem response (ABR) thresholds from 3-4 months to 9-10 months of age at frequencies of 8, 16, and 32 kHz. In contrast, FAD2 mice showed significant threshold elevations at 9-10 months, with greater impairment at higher frequencies and in females. Interestingly, both sexes of

SUBMITTER: Su H 

PROVIDER: S-EPMC12867125 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature