Targeting lymphatic vessels enhances bone regeneration by augmenting osteoclast activity in mouse models of amputation.

ABSTRACT: Although mammals generally demonstrate limited regenerative capacity compared with amphibians, the digit tip retains remarkable regenerative potential, providing a useful model to study successful mammalian regeneration. This process involves coordinated immune cell activity, vascular remodeling, and tissue reconstruction, yet the molecular checkpoints controlling regenerative versus fibrotic outcomes remain poorly understood. In mammals, regeneration of the digit tip (P3) proceeds through myeloid cell migration, early osteoclast-mediated osteolysis of the distal bone, and subsequent blastema-mediated regeneration. Here we test the hypothesis that lymphatic vessels regulate regenerative capacity by modulating local immune cell dynamics and osteoclast function. Using a lymphatic system-spec

SUBMITTER: Vishlaghi N 

PROVIDER: S-EPMC12867134 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature