Identifying chemicals associated with irritable bowel syndrome by integrating a transcriptome-wide association study with chemical-gene-interaction analysis.

ABSTRACT:

Background

Irritable bowel syndrome (IBS) is a prominent functional gastrointestinal disorder, yet the precise causes and mechanisms behind it remain largely unclear. Numerous environmental compounds have been associated with the intestinal health of individuals suffering from IBS. This study sought to explore the impact of environmental chemicals on the condition of IBS.

Methods

We analyzed genome-wide association study (GWAS) data comprising 455,321 individuals of white British descent, among which 28,518 individuals with IBS underwent transcriptome-wide association study (TWAS) analysis. Reference gene expression data were sourced from tissues including the small intestine, transverse colon, sigmoid colon, whole blood, and peripheral blood.

Results

Gene Ontology an

SUBMITTER: Zhao X 

PROVIDER: S-EPMC12867268 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature