Functional proteomic analysis reveals <i>mglB</i>-mediated meropenem resistance and its reversal by galactose.

ABSTRACT: Salmonella enteritidis is a globally prevalent zoonotic pathogen with a broad host range and high pathogenicity, ranking among the most common serotypes within the Salmonella genus. The widespread and often indiscriminate use of antibiotics has driven a continual rise in antimicrobial resistance among S. Enteritidis strains, posing a significant threat to public health. In this study, we employed a quantitative proteomics approach to investigate differential protein expression between meropenem-sensitive and -resistant S. Enteritidis strains. Bioinformatic analyses revealed significant downregulation of all the genes associated with the bacterial chemotaxis pathway in the resistant strain. To further explore the functional relevance of this pathway, we generated deletion mutants of

SUBMITTER: Li X 

PROVIDER: S-EPMC12867356 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature