The interaction between CfAda3 and CfGcn5 impacts growth, development, and virulence of <i>Colletotrichum fructicola</i>.

ABSTRACT: Camellia oleifera is an important economic woody oil plant in many Asian countries, and the anthracnose caused by Colletotrichum fructicola is prevalent in its cultivation regions, causing significant losses annually. We previously found that CfGcn5-mediated H3 acetylation governs virulence of C. fructicola. To further elucidate the regulatory mechanism of CfGcn5, we carried out mass spectrometry analysis for CfGcn5-interacting proteins and identified CfAda3 protein for functional analysis. We found that CfAda3 was mainly localized in nucleus and cooperated with CfGcn5 to acetylate H3K18 for global gene transcription. Targeted gene deletion revealed that CfAda3 is involved in growth and conidiation. Similar to ΔCfgcn5 mutant, the ΔCfada3 mutant is defecti

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12867434 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature