Timing of adjuvant radiotherapy for early-stage endometrial carcinoma: a single-center retrospective cohort study.

ABSTRACT:

Objective

To investigate the appropriate timing of radiotherapy (RT) after hysterectomy in women with early-stage endometrial cancer (EC).

Methods

We analyzed the data of 1,062 patients with early-stage EC who underwent postoperative RT at our hospital between April 1999 and November 2020. Restricted cubic spline were used to explore the relationship between the surgery-radiotherapy interval (SRI) and local recurrence-free survival (LRFS). The maximally selected rank statistics method was used to identify the optimal threshold for SRI. The overall survival (OS), disease-free survival (DFS), LRFS, and distant metastasis-free survival (DMFS) rates were estimated using the Kaplan-Meier method. Multivariate analysis was performed using the Cox proportional hazards regression.

SUBMITTER: Yan Z 

PROVIDER: S-EPMC12867659 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature