Tumour priming by ultrasound mechanogenetics for CAR T therapy.

ABSTRACT: Cell-based cancer immunotherapy holds potential as a therapeutic approach, yet its application for solid tumour treatment remains challenging. Here we report a focused-ultrasound-based approach that mechanically induces the localized expression of CD19 antigen within a subpopulation of cells within solid tumours, which function as local 'training centres' to activate chimeric antigen receptor T cells. Activated chimeric antigen receptor T cells attack the whole cancer cell population near the tumour site, thus achieving cancer suppression. The system achieves targeted gene expression by integrating focused-ultrasound-triggered mechanical stimulation and the subsequent calcium response of cancer cells with a doxycycline-gated AND-logic genetic circuit, both of which need to be active for ef

SUBMITTER: Yoon CW 

PROVIDER: S-EPMC12867766 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature