Cross-tissue transcriptome-wide association identify novel T1D susceptibility genes and drug candidates.

ABSTRACT:

Background

The genetic mechanisms underlying type 1 diabetes (T1D) remain incompletely understood, limiting the development of targeted therapies.

Methods

We performed an integrative genetic analysis to identify T1D susceptibility genes and therapeutic targets. This included a cross-tissue transcriptome-wide association study (TWAS) to pinpoint genes with genetically predicted expression associated with T1D risk, followed by Mendelian randomization to infer causality. Identified genes were further characterized through pathway, cell-type enrichment, drug prediction, molecular docking, and phenome-wide association studies.

Results

We identified ten genes associated with T1D risk, seven of which (ELK4, PHACTR4, MAST2, ST7L, C1orf216, SULT1A2, and WFS1) are novel candida

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12867781 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature