Anti-colorectal cancer effects of IRX4 and sensitivity studies to oxaliplatin.

ABSTRACT:

Introduction

Colorectal cancer (CRC) remains one of the most lethal malignancies globally. Chemoresistance or reduced chemosensitivity is a key factor contributing to treatment failure in CRC, particularly in patients with advanced-stage disease. Iroquois homeobox protein 4 (IRX4), a transcription factor expressed in multiple tissues, has been demonstrated to be implicated in the progression of many cancers. Based on this background, IRX4 identified through Illumina Infinium 935K methylation chip analysis was chosen to explore its potential role in CRC.

Methods

Following initial screening via the Illumina Infinium 935K methylation chip, we further confirmed the hypermethylation of IRX4 in CRC tissues using pyrosequencing technology. The expression levels of IRX4 were determi

SUBMITTER: Jia M 

PROVIDER: S-EPMC12867854 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature