FOXC1 expression and radiological predictors of peritumoral brain edema in meningiomas.

ABSTRACT:

Background

Peritumoral brain edema (PTBE) is a frequent finding in meningiomas and can significantly affect perioperative outcomes. In addition to well-established clinical, radiological, and histopathological risk factors, molecular markers such as Forkhead Box C1 (FOXC1) may also play a crucial role in the development of PTBE.

Methods

We conducted a retrospective, single-center study including 86 patients with histopathologically confirmed meningiomas. Preoperative MRI datasets were analyzed for tumor characteristics using 3D Slicer and ImageJ. FOXC1 expression was assessed immunohistochemically and dichotomized based on receiver operating characteristic (ROC) curve analysis. Univariate analyses were performed to evaluate associations between clinical, radiological, and hi

SUBMITTER: Basaran AE 

PROVIDER: S-EPMC12868038 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature