The effects of the PHF6 gene mutation on myeloid neoplasms. A single-center cohort underpinned by a systematic review of literature.

ABSTRACT: The mutation of the plant homeodomain finger protein 6 gene (PHF6^MUT) in patients with myeloid neoplasms (MNs) is rare and appears to play a role in prognosis, though this is still under debate. We conducted a retrospective analysis of a cohort of 313 patients diagnosed with MNs. We also performed a systematic review (SR) of the literature to evaluate the prognostic role of PHF6 gene status in MNs. We identified 15 patients with PHF6^MUT. In the multivariate analysis, PHF6^MUT was associated with higher mortality compared to PHF6^{wild - type} (hazard ratio [HR] = 1.02; 95% confidence interval [CI], 1.00-1.05; P = 0.075), with no apparent impact from other co-mutations. In the multilevel logistic model by MN subtype, the presence of PHF6^MUT

SUBMITTER: Suarez EU 

PROVIDER: S-EPMC12868061 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature