A randomized, double-blind, placebo-controlled trial of soluble corn fiber supplementation for children with asthma.

ABSTRACT:

Introduction

Asthma is a multifactorial disease influenced by genetic and environmental factors, including diet. The gut microbiome contributes to airway inflammation via the gut-lung axis, partly through production of short chain fatty acids (SCFAs) from bacterial fermentation of dietary fiber. We hypothesized that dietary fiber supplementation could modulate the gut microbiome and increase SCFAs in children with asthma.

Methods

This is a double-blind, placebo-controlled trial of children who were randomized to consume 12 g of soluble corn fiber (SCF) as a supplement to their usual daily diet (50% the recommended daily fiber intake) or placebo for 4-6 weeks (clinicaltrials.gov NCT03673618). Dietary surveys, asthma symptom questionnaires, fecal, blood and nasal samples were

SUBMITTER: Rank MA 

PROVIDER: S-EPMC12868147 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature