Designing a broad-spectrum multi-epitope vaccine against influenza A and <i>Mycoplasma pneumoniae</i>: an immunoinformatics approach.

ABSTRACT:

Introduction

Influenza A and Mycoplasma pneumoniae (M. pneumoniae) are common respiratory pathogens, causing severe co-infections in clinical diseases. Current vaccines have failed to provide comprehensive protection against both of the pathogens, highlighting the requirement of integrated solution.

Methods

In this study, a novel dual-target multi-epitope vaccine was developed based on the immunoinformatics method. Based on the consistent sequences, we used the HA and NA proteins of influenza A virus, and the p1, p65, HMW1-3 proteins of M. pneumoniae to determine the immunodominant T- and B-cell epitopes.

Results and discussion

The designed vaccine included 21 linear B-cell epitopes, 34 CTL epitopes and 19 HTL epitopes from influenza A virus and <

SUBMITTER: Yang Z 

PROVIDER: S-EPMC12868154 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature