Association of oral microbiota and digestive system cancers revealed by bidirectional two sample Mendelian randomization.

ABSTRACT:

Background

Growing evidence suggests that there is a link between the oral microbiota and the development of digestive system cancers (DSCs). Nonetheless, the causal relationship between the oral microbiota and DSCs has yet to be established.

Methods

To evaluate the causal relationship between oral microbiota and DSCs, we employed Genome-wide association study (GWAS) summary statistics for both oral microbiota and DSCs, in conjunction with bidirectional two-sample Mendelian randomization (MR) analysis. Single nucleotide polymorphisms, which were free from confounding factors, were used as instrumental variables to infer causation. Sensitivity analyses were conducted to assess the robustness of our findings. This study employed datasets encompassing a wide range of cancer cas

SUBMITTER: Zhang YJ 

PROVIDER: S-EPMC12868531 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature