Defective cell-autonomous signalling and antigenic polyreactivity of B-cell receptors from chronic lymphocytic leukaemia stereotyped subset 1.

ABSTRACT: A shared feature of B-cell receptors (BCRs) expressed on neoplastic B cells from patients with chronic lymphocytic leukaemia (CLL) concerns their continual activation of intracellular signalling without requiring external antigens. This autonomous signalling mechanism has previously been demonstrated to arise from BCR-BCR homotypic interactions in three distinct stereotyped CLL subsets (2, 4 and 169). CLL subset 1 is the second largest stereotyped subset, epitomizing unmutated CLL and known for a particularly aggressive clinical course. Here we show that, despite their significant sequence similarity, BCRs originating from three different subset 1 CLL cases exhibit variations in their combining site structures and associated physicochemical properties. Subset 1 BCRs are characterized by a

SUBMITTER: Cocomazzi PG 

PROVIDER: S-EPMC12868647 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature