PRRs-related genes and immune landscape in heart failure and COPD.

ABSTRACT: Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are major health issues causing high hospitalization and mortality rates. Pattern recognition receptor-related differentially expressed genes (PRDEGs) play a crucial role in disease progression, as their altered expression patterns are closely linked to immune responses, inflammatory processes, and tissue remodeling. Understanding PRDEGs is vital for effective diagnostics and therapies. This study incorporated four GEO datasets (GSE57338, GSE16499, GSE76925, and GSE57148). Among them, GSE57338 and GSE76925 served as the primary analysis sets for HF and COPD, respectively, where differential expression, functional enrichment, and immune infiltration analyses were performed. GSE16499 and GSE57148 were used as independent val

SUBMITTER: Yang H 

PROVIDER: S-EPMC12868864 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature