PEBL, a component-based Chinese medicine, reduces virus-induced acute lung injury by targeting FXR to decrease ACE2 levels.

ABSTRACT:

Introduction

Despite the growing clinical need, the therapeutic efficacy of drugs for acute lung injury (ALI) remains inadequate. Traditional Chinese Medicine (TCM) holds potential in managing ALI due to its unique therapeutic properties. However, the intricate nature of TCM formulations hinders global adoption. Component-based Chinese medicine (CCM) offers a promising pathway for TCM's internationalization. Phillyrin-Emodin-Baicalin-Liquiritin (PEBL), a CCM with significant anti-inflammatory activity, is derived from the well-established TCM formula Liang-Ge-San. Whether PEBL effectively addresses viral ALI, however, remains unclear.

Objectives

This study aims to investigate the therapeutic effects and underlying mechanisms of PEBL on viral ALI.

Methods

The efficacy

SUBMITTER: Yang L 

PROVIDER: S-EPMC12869212 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature