Hyperoside modulates bile acid and fatty acid metabolism, presenting a potentially promising treatment for non-alcoholic fatty liver disease.

ABSTRACT:

Introduction

Non-alcoholic fatty liver disease (NAFLD) is a multifactorial chronic condition that requires a systematic approach for effective management. Multi-effect therapeutic drugs derived from traditional Chinese medicine are increasingly being recognized as promising alternatives for NAFLD intervention. Hyperoside, a natural flavone glycoside found in Cuscuta chinensis Lam, Forsythia suspensa, and Crataegus pinnatifida Bge, has been shown to effectively mitigate NAFLD in rats. However, the underlying mechanism through which hyperoside alleviates NAFLD remains unclear.

Objective

This study aims to explore the specific mechanisms by which hyperoside intervenes in the progression of NAFLD.

Methods

In this study, a high-fat diet was used to induce the NAFLD model i

SUBMITTER: Wang S 

PROVIDER: S-EPMC12869213 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature