JAM-C prevents ocular fibrosis by suppressing the TAZ/KLF6 pathway.

ABSTRACT:

Introduction

Ocular fibrosis is one of the leading causes of irreversible visual impairment or blindness. Currently, there is no effective drug available for such diseases. Therefore, understanding the underlying mechanisms is a prerequisite for finding better therapeutic strategies.

Objectives

This study aims to investigate the role of the junctional adhesion molecule C (JAM-C) in ocular fibrosis.

Methods

The protein levels of JAM-C were determined in the vitreous humor samples of patients with ocular fibrosis using ELISA. Jam-c genetic deletion mice and ocular fibrosis mouse models were generated to study the role of JAM-C in vivo. EMT, proliferation, migration, and gel contraction capacities in RPE cells were examined after JAM-C knockdown by siRNAs. RNA sequencing

SUBMITTER: Chen M 

PROVIDER: S-EPMC12869230 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature