Clostridium butyricum and its metabolites regulate macrophage polarization through miR-146a to antagonize gouty arthritis.

ABSTRACT:

Introduction

Gut microbiota modulation has recently been identified as a prospective avenue for the exploration of novel therapeutic strategies for the management of gout. Nevertheless, the application of a single specific strain or bacterial metabolite for gout intervention has rarely been explored and the underlying regulatory mechanism remains elusive.

Objectives

To ascertain the potential role and the molecular mechanism of Clostridium butyricum and butyrate in the management of gouty arthritis.

Methods

A Uox-KO mouse model of gouty arthritis was developed and the composition of the gut microbiota was analyzed. C. butyricum and butyrate were supplemented to assess functional recovery and intestinal homeostasis. NanoString analysis identified miRNA variations. GC/M

SUBMITTER: Song S 

PROVIDER: S-EPMC12869238 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature