Gastrodin enhances stress resilience through promoting Wnt/β-Catenin-dependent neurogenesis.

ABSTRACT:

Background

Enhancing stress resilience constitutes a pivotal strategy in mitigating the risk of depression, making it a critical component of both prevention and treatment. In the current work, we identified a compound, gastrodin (GAS), as capable of enhancing stress resilience, as demonstrated by its ability to protect against depression following chronic stress exposure.

Objectives

To elucidate the potential of GAS to promote neurogenesis under chronic stress, along with the associated cellular and molecular processes involved.

Method

We evaluated the effect of GAS on NSPC proliferation and differentiation using both in vitro and in vivo investigations. Neurogenesis was inhibited using temozolomide to verify GAS's impact on stress resilience. Comprehensive methodolo

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12869260 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature