A smart nanocomposite bioactive ink for controlled siRNA delivery in calvarial mesenchymal stromal cells as a minimally invasive treatment for craniosynostosis.

ABSTRACT: Craniosynostosis (CS), characterized by the premature fusion of cranial sutures, often results from aberrant activation of Fibroblast growth factor receptor 2 (FGFR2), a major regulator of osteogenic differentiation in cranial mesenchyme. Despite surgical interventions, recurrence and complications remain common, underscoring the need for targeted molecular therapies. In this study, we developed a novel formulation of bioactive nanocomposite hydrogel-based ink designed for localized, sustained delivery of therapeutic small interfering RNAs (siRNAs) targeting FGFR2. The delivery system combines gelatin methacryloyl (GelMA), a biocompatible and photo-crosslinkable hydrogel, with poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs), creating an injectable and mouldable platfo

SUBMITTER: Salvati M 

PROVIDER: S-EPMC12869795 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature