In Vivo Classification of Oral Lesions Using Electrical Impedance Spectroscopy.

ABSTRACT:

Objective

To evaluate a new non-invasive, handheld Electrical Impedance Spectroscopy (EIS) device for assessing oral lesions in real-life surgical scenarios.

Methods

A custom-designed probe with a 33-electrode sensor array was used to collect impedance measurements across multiple frequencies (100 Hz - 100 kHz) from non-consecutive patients undergoing surgical resection of oral cancer. In vivo EIS measurements were recorded from lesion and healthy tissue surfaces before resection, with no clinical decisions based on impedance data.

Results

The study included 26 participants (median [IQR] age, 64.3 [59 - 70] years; 11 (42%) female) with oral squamous cell carcinoma. Cancerous tissue was found to have significantly lower resistance and reactance than healthy tissue (p<0

SUBMITTER: Lloyd SA 

PROVIDER: S-EPMC12869821 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature