Testing menstrual blood for human papillomavirus during cervical cancer screening in China: cross sectional population based study.

ABSTRACT:

Objective

To compare the diagnostic accuracy of minipad collected menstrual blood versus clinician collected cervical samples to test for human papillomavirus (HPV) in the detection of cervical intraepithelial neoplasia grade 2/3 or worse (CIN2+/CIN3+).

Design

Cross sectional population based study.

Setting

Four urban and three rural communities in Hubei Province, China.

Participants

3068 women aged 20-54 years with regular menstrual cycles, enrolled between September 2021 and January 2025.

Interventions

HPV testing using minipad collected menstrual blood, clinician collected cervical samples, and ThinPrep cytology. Women who tested HPV positive by either collection method or by cytology (atypical squamous cells of undetermined significance or worse) wer

SUBMITTER: Tian X 

PROVIDER: S-EPMC12869892 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature