Genome-wide identification of GAPDH gene family and functional analysis of CaGAPC2-mediated autophagy during BWYV infection in pepper.

ABSTRACT:

Background

Glyceraldehyde-3-phosphate dehydrogenases (GAPDHs) are glycolytic enzymes involved in plant metabolism, growth, signal transduction and stress responses. Beet western yellows virus (BWYV), which belongs to the Polerovirus, causes substantial yield and quality losses in pepper. However, the roles of GAPDHs in pepper responses to BWYV infection remain largely unexplored.

Results

Transcriptome analyses revealed altered expression of GAPDH genes in Capsicum annuum following BWYV infection. Genome-wide analysis identified seven CaGAPDH genes in pepper, and qRT-PCR showed that CaGAPC2 transcripts were most strongly down-regulated after infection. Previous studies have shown that GAPCs contribute to autophagy regulation. Here, silencing CaGAPC2 enhances autophagy and red

SUBMITTER: Yang W 

PROVIDER: S-EPMC12869920 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature