Evolutionary genomics of KPC-2-producing Serratia marcescens and characterization of a novel bla_KPC-2-harboring plasmid.

ABSTRACT:

Background

Serratia marcescens is a common opportunistic pathogen in hospitals. Its carbapenem-resistant strains, especially those carrying the bla_KPC-2 gene, pose a serious challenge to clinical infection treatment.

Methods

In this study, we identified 14 strains that were positive for bla_KPC-2 from tertiary hospitals in Zhejiang Province, China, through phenotypic tests and sequencing. We also incorporated data from the GenBank public database, resulting in a total of 2005 Serratia strains included for bioinformatic analysis.

Results

A total of 121 strains (6.03%) were found to carry bla_KPC-2. These positive isolates predominantly originated from China (76.86%) and the United States (14.88%), with the vast majority (94.21%) identifie

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC12869953 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature