Ruminal microbiota-derived inosine alleviates metabolic disorders in dairy cows supplemented with grape seed extract.

ABSTRACT: Ruminal microbiota and their metabolites can shape host metabolic responses. Grape seed extract (GSE) can modulate ruminal microbiota profiles and metabolites in vitro, thus, underscoring their potential benefits on energy metabolism in dairy cows. In this study, Chinese Holstein cows were randomly divided into two groups (n = 10 per group) with or without dietary supplementation of GSE (15 g/d per cow) from -3 to 3 wk relative to calving. The results showed that GSE supplementation led to increased fat corrected milk yield (P = 0.003), feed efficiency (P = 0.045) and reduced milk somatic cell count (P = 0.031). In addition, GSE resulted in greater overall serum glucose (P = 0.011) and lower non-esterified fatty acids (P < 0.001), β-hydroxybutyric

SUBMITTER: Shao Q 

PROVIDER: S-EPMC12870047 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature