GP6 polymorphisms and venous thromboembolism: a Chinese case-control study with cross-population assessment.

ABSTRACT:

Background

While genome-wide association studies having implicated the GP6 rs1613662 polymorphism as a risk factor for venous thrombosis, subsequent studies have reported inconsistent findings regarding this association.

Objectives

Here, we performed a case-control study in a Chinese cohort to evaluate the association between rs1613662 and venous thromboembolism (VTE) risk. We further conducted‌ a comprehensive cross-population assessment by integrating multi-ethnic data to assess this association.

Methods

We recruited 225 patients with VTE and 203 healthy controls for the Chinese case-control study, with rs1613662 genotyped using the Sequenom assay. Additionally, we systematically integrated genotyping data from nine cohorts (with a total of 5,669 VTE cases and 8,976

SUBMITTER: Fu Y 

PROVIDER: S-EPMC12870193 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature