The impact of testosterone on paraventricular nucleus gene expression in male and female spontaneously hypertensive rats.

ABSTRACT:

Background

Hypertension is a polygenic, complex disease that impacts men and women differently; whilst the incidence of high blood pressure (BP) is roughly equal over a lifetime, men typically are at higher risk of developing the disease earlier in life, before 50 years of age. There is adequate evidence that the brain is critical for the BP setpoint. The paraventricular nucleus (PVN) of the hypothalamus is an integrative structure that can influence not only neurohumoral responses to blood pressure changes, but also sympathetic drive. Here we manipulate the androgenic status of both male and female spontaneously hypertensive rats (SHRs) to determine how this changes gene expression within the PVN of these animals.

Methods

SHR (8-weeks old) were either sham-operated or orchi

SUBMITTER: Paterson A 

PROVIDER: S-EPMC12870226 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature