Mitochondrial-related biomarkers as the diagnostic markers in sepsis induced acute respiratory distress syndrome.

ABSTRACT: Previous study found that mitochondrial might correlate with sepsis-induced acute respiratory distress syndrome (ARDS). Thus, this study aimed to find the effect of mitochondrial-related biomarkers in sepsis-induced ARDS. Differentially expressed genes (DEGs) were firstly screened in sepsis-induced ARDS datasets and intersected with mitochondrial-related genes (MRGs) to create differentially expressed-MRGs (DE-MRGs). Based on DE-MRGs, three machine learning algorithms were further performed to yield feature genes, the intersections of feature genes were conducted expression analysis. Those genes with significant difference of expression were identified as biomarkers for nomogram construction and immune infiltration. Single cell RNA sequencing (scRNA-seq) analysis was processed to annotate

SUBMITTER: He Y 

PROVIDER: S-EPMC12870294 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature