Longitudinal clinical proteomics reveals pneumonia type-specific protein biomarkers and autoantibodies.

ABSTRACT: Community-acquired pneumonia is a major cause of morbidity and mortality globally. Specific molecular endotypes are currently not well defined and different viral or bacterial pathogens may trigger specific host responses and pathogenic mechanisms. We performed longitudinal proteomic profiling of bronchoalveolar lavage fluid and plasma from bacterial, influenza and SARS-COV-2 driven pneumonia. Our analysis revealed highly pneumonia type specific proteomic signatures, including COVID-19 specific antibodies locally produced in the lung. These antibodies showed biased immunoglobulin V-domain usage, linked to a CD69/CD83 plasma cell state associated with disease severity and degree of autoimmunity. Using mass spectrometry driven autoantibody profiling in two independent COVID-19

SUBMITTER: Semenova A 

PROVIDER: S-EPMC12870487 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature