Dataset Information
Multi-omics and machine learning reveal DPPC as a key contributor to colorectal cancer progression and tumor immune microenvironment remodeling.
Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC12870534 | biostudies-literature | 2026 Jan
REPOSITORIES: biostudies-literature
Publications
Multi-omics and machine learning reveal DPPC as a key contributor to colorectal cancer progression and tumor immune microenvironment remodeling.
Journal of translational medicine 20260102 1
BACKGROUND: Although previous studies have linked colorectal cancer (CRC) with lipid metabolism and inflammatory signaling, the specific roles of phosphatidylcholine metabolites and their interactions with inflammatory cytokines in the tumor microenvironment remain poorly understood. METHODS: This study utilizes an integrated multi-omics analysis approach. We performed a two-sample Mendelian randomization analysis using data from 1400 metabolites and 91 inflammatory cytokines to investigate thei ...[more]