The association of osteoarthritis with the risk of de novo inflammatory arthritis in patients receiving immune checkpoint inhibitors: a retrospective study.

ABSTRACT:

Objective

Identifying risk factors enables stratification of patients' susceptibility to inflammatory arthritis immune-related adverse events (IA-irAE). This retrospective study examines whether preexisting osteoarthritis (OA) increases the likelihood of de novo IA in patients treated with immune checkpoint inhibitors (ICIs).

Methods

The prevalence of OA among ICI-treated patients who developed IA-irAE, those who developed other types of irAEs but not IA (non-IA irAE), and those who did not develop any irAEs (non-irAE) were compared. Electronic medical records were reviewed to extract demographic, clinical and laboratory data. Group comparisons and logistic regression analyses were performed.

Results

181 de novo IA-irAE patients, 140 non-IA irAE patients

SUBMITTER: Chen S 

PROVIDER: S-EPMC12870556 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature