Alveolar Immune Profiling Identifies Distinct Subphenotypes of Acute Respiratory Failure.

ABSTRACT: Acute respiratory failure causes millions of deaths worldwide each year, highlighting the need for a better understanding of its pathophysiology and approaches to identify treatment-responsive subphenotypes of patients. Although subphenotypes of acute respiratory failure have been described using peripheral blood biomarkers, it remains unclear whether lung-specific molecular profiles can define biologically and clinically meaningful subphenotypes. In this study, we identified four distinct subphenotypes based on the measurement of twenty-five soluble proteins in alveolar fluid collected from 466 patients with acute respiratory failure. Forty-eight of these participants also underwent immunophenotyping by spectral flow cytometry to characterize immune cell populations. Twenty-eight-day mort

SUBMITTER: Morrell ED 

PROVIDER: S-EPMC12870558 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature