Association of GLP-1 Receptor Agonist Prescriptions and Alcohol Consumption in the National Institutes of Health's <i>All of Us</i> Cohort.

ABSTRACT:

Importance

Alcohol use is a leading cause of morbidity and mortality worldwide. Growing evidence suggests that glucagon-like peptide-1 receptor agonists (GLP-1RAs) may represent a novel potential pharmacotherapeutic tool for alcohol use disorder (AUD).

Objective

To examine the association between GLP-1RA prescriptions and alcohol use.

Design

This cohort study used a cross-sectional measure of alcohol consumption and longitudinal electronic health record (EHR) data collected between 1981 and October 2023 from NIH's All of Us Research Program participants.

Setting

All of Us is a large program to recruit and collect surveys, EHR, genomic, and wearable data from a wide array of Americans. The data presented here are from the All of Us Curated D

SUBMITTER: Tyndall B 

PROVIDER: S-EPMC12870566 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature