Integrating multi-omic QTLs and predictive models reveals regulatory architectures at immune related GWAS loci in CD4+ T cells.

ABSTRACT: Functional interpretation is essential for understanding how genetic variants contribute to complex traits. Here, we identified and characterized regulatory variants in CD4+ T cells collected from 362 donors. We integrated molecular QTL mapping from single-cell RNA-seq profiles and chromatin accessibility with predicted variant effects from a deep learning model trained on chromatin accessibility data. We identified molecular features and transcription factor binding mechanisms underlying variant sharing and mediated effects across the modalities and approaches. While predicted variant effects correlated with molQTLs, only a small fraction of empirically detected molQTLs were discovered by predictive models. MolQTLs, primarily those affecting chromatin, indicated potential molecular driver

SUBMITTER: Matos MR 

PROVIDER: S-EPMC12870616 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature