Age-dependent Genetic Risk in Pulmonary Fibrosis Patients and Relatives.

ABSTRACT:

Rationale

Idiopathic pulmonary fibrosis (IPF) is an age-related disorder with common and rare genetic risk factors. It is unknown if the effects of PF genetic risk factors differ by chronologic age.

Objectives

To assess age-specific effects of genetic risk factors in PF patients and their relatives.

Methods

We identified common and rare genetic risk factors using a Columbia whole genome sequencing (WGS) cohort (777 IPF, 2905 controls) and replicated findings using Trans-Omics for Precision Medicine (TOPMed, 1148 IPF, 5202 controls). We assessed age-stratified genetic risk of IPF and assessed for interaction with age across a range of cutoffs. We analyzed 313 FPF pedigrees and compared age-specific prevalence of interstitial lung disease in relatives stratified by prob

SUBMITTER: Zhang D 

PROVIDER: S-EPMC12870627 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature