Substance use disorders exhibit unique and disorder specific genetic associations with externalizing and internalizing psychopathology.

ABSTRACT:

Background and aims

Substance use disorders (SUDs) are heritable and share genetic variance with externalizing and internalizing psychopathology. Although recent gene identification efforts have demonstrated the value of modeling the shared genetic architecture among SUDs and externalizing, most research has thus far failed to account for overlap with internalizing. In this study, we aim to characterize the genetic relationships of both externalizing and internalizing with SUDs.

Design and setting

We used genome-wide association study (GWAS) summary statistics derived from previously published studies of externalizing, internalizing, and SUD outcomes to quantify the genetic overlap between these phenotypes. We characterize this overlap using omnibus, partial, and local genet

SUBMITTER: Poore HE 

PROVIDER: S-EPMC12870668 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature