Empirical limitations of current low-intensity focused ultrasound simulation platforms.

ABSTRACT: Transcranial low-intensity focused ultrasound (LIFU) is an emerging tool for noninvasive neuromodulation, with potential therapeutic applications across a range of neuropsychiatric disorders. As the field advances toward clinical translation, individualized simulations of sonication parameters are critical for estimating dosing to ensure safety, efficacy, and reproducibility. Currently, k-Plan (Brainbox Ltd.) and BabelBrain (open-source) are two widely used software packages for sonication simulation, yet their outputs have not been empirically compared. In this study, we directly evaluated the consistency of simulation results produced by these two platforms when applied to the same individuals, trajectories, and sonication protocols. We further examined the impact of skull

SUBMITTER: Brandts SD 

PROVIDER: S-EPMC12870687 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature