Epigenetics in Abdominal Aortic Aneurysm: Mechanisms and Risk Prediction.

ABSTRACT:

Background

Epigenetic mechanism underlying susceptibility to abdominal aortic aneurysm (AAA) remain poorly understood. Identifying causal DNA methylation markers for AAA can elucidate the regulatory processes that drive aneurysm formation and would accelerate translational applications. We leveraged the VA Million Veteran Program (MVP) to identify methylation biomarkers and delineate underlying pathways.

Methods

We first conducted an epigenome-wide association study (EWAS) of incident AAA (1,324 cases; 42,065 non-cases), performed stratified analyses by population group and smoking status, and conducted Mendelian randomization (MR) to facilitate casual inference of the CpG-AAA association. Chromatin state, island context, and TF binding were implicated through functional ann

SUBMITTER: Yuan S 

PROVIDER: S-EPMC12870697 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature