Sex differences in LDL-C genetic architecture and statin efficacy in All of Us.

ABSTRACT: Low-density lipoprotein cholesterol (LDL-C) is a well-established and modifiable risk factor for cardiovascular diseases (CVDs), which has been the leading cause of mortality among women and men in the United States since 1921. Despite research demonstrating sexually dimorphic symptom presentation of CVD, women remain underdiagnosed and undertreated for CVDs relative to men. Using genotype and phenotype data from the All of Us (AoU) Research Program, we examined sex-specific differences in LDL-C measurements, including baseline levels, statin treatment efficacy, age-related patterns, genome-wide association study (GWAS) results, and heritability between women and men. We find that the median LDL-C measurements of women are consistently higher than those of men across all age strata and tha

SUBMITTER: Liquori JL 

PROVIDER: S-EPMC12870709 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature