Elevated Plasma Monounsaturated Fatty Acids and Their Associations with Disease Activity, Adiposity, and Sex in Patients with Rheumatoid Arthritis: A Cross-Sectional Study.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by metabolic dysregulation, including altered lipid metabolism. While polyunsaturated fatty acids have been studied, the plasma levels, endogenous synthesis, and relevance of monounsaturated fatty acids (MUFAs) in RA remain unclear. This study examined plasma MUFA levels in RA and their associations with disease activity, adiposity, and intake.

Methods

In this cross-sectional study, 59 individuals with rheumatoid arthritis (RA) and 33 non-RA controls frequency-matched on age, sex, and BMI were recruited between 2017 and 2022. Clinical assessments included disease activity (DAS28), body composition, and metabolic parameters. Dietary intake was assessed using a 4-day food journal, and plasma f

SUBMITTER: Swamy SN 

PROVIDER: S-EPMC12870717 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature