Integrated genomics and metabolomics analysis revealed the metabolic mechanisms by which genetic variations affect the growth performance of local chickens.

ABSTRACT: Although many studies have examined the relationship between host genetics and serum metabolites, it is still unclear to what extent host genetic variation contributes to growth-related serum metabolic patterns in chickens. To address this issue, we performed whole-genome resequencing, transcriptome sequencing, and untargeted metabolomics analyses on blood samples collected from a population of Chinese local chickens. The results showed that single-nucleotide polymorphisms (SNPs) significantly associated with growth performance were predominantly mapped the genomic regions of SEC22C, ABCD3, SRGAP2, and CDC42BPA. SEC22C, ABCD3, and SRGAP2 were significantly associated with both body weight (BW) and average daily gain (ADG), whereas CDC42BPA was significantly associated only with ADG. Compar

SUBMITTER: Yang X 

PROVIDER: S-EPMC12870779 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature