Investigating predictors of pain events during trials of knee osteoarthritis: A post-hoc analysis of two phase III trials.

ABSTRACT:

Objective

This study aims to explore the associations between clinical characteristics, including medical history, and the frequency, severity, and type of pain events (PEs) over a two-year period in patients with knee osteoarthritis (OA).

Design

A post-hoc analysis was conducted on data from two double-blinded, randomized, placebo-controlled, multicenter phase-III trials assessing the efficacy and safety of salmon calcitonin in patients with painful and radiographic knee OA. 2206 patients aged 51-80 years were included. Adverse events (AEs) were recorded and categorized into PEs and non-PEs. Logistic regression models were used to assess associations, adjusting for confounders such as age, sex, and body mass index (BMI).

Results

Of the 8183 AEs recorded, 27.6 % were

SUBMITTER: Kaaber AB 

PROVIDER: S-EPMC12870780 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature