IL-27 signaling mediates skin inflammation in experimental psoriasis and atopic dermatitis.

ABSTRACT:

Background

Psoriasis and atopic dermatitis (AD) are two prevalent inflammatory skin disorders, each characterized by distinct adaptive immune responses. However, recent evidence suggests that these diseases may share overlapping immune mechanisms, especially concerning keratinocyte function. The specific cytokines that coordinate these inflammatory pathways remain largely undefined.

Methods

The expression of IL-27 and its receptor was analyzed using data derived from GEO datasets. Imiquimod-induced psoriasis-like and MC903-induced AD-like skin inflammation models were established in wild-type and Il27ra knockout littermates. Skin inflammation was evaluated using clinical scoring, histology, and immunostaining. Flow cytometry was employed to characterize immune cell populatio

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12870830 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature