Serinc2-STAT3 protects against doxorubicin-induced cardiotoxicity via promoting mitochondrial bioenergetics.

ABSTRACT:

Objective

Doxorubicin (DOX) is a highly effective anthracycline chemotherapy drug that is commonly used in clinical practice. Because of the accumulation of its drug concentration, their clinical use is associated with severe cardiotoxicity. Serine incorporator 2 (Serinc2) had been shown to play an important role in maintaining cell structure and function. Here, the main purpose of this study was to explore the effect of Serinc2 on doxorubicin-induced cardiotoxicity and its mechanism.

Methods

Global Serinc2 knockout (Serinc2-KO) and cardiac-specific Serinc2 overexpression mice received a single or repeated DOX injection to establish chronic cardiotoxicity. Cardiac function, oxidative damage, cell apoptosis, and mitochondrial profiles were evaluated. Transcriptome and co-immu

SUBMITTER: Hu S 

PROVIDER: S-EPMC12870868 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature