Biomimetic "Tendon Band-Aid" regulates inflammatory microenvironment and tenogenic differentiation for tendinopathy regeneration.

ABSTRACT: Tendinopathy (TDP) is a common yet challenging chronic degenerative condition characterized by disrupted inflammatory microenvironments, cellular dysfunction and tissue structural degradation. Drawing inspiration from the protective and drug-releasing functions of adhesive bandages, this study has developed a biomimetic "Tendon Band-Aid" using electrospinning and photocrosslinking techniques to modulate anti-inflammatory and regenerative processes within the tendon microenvironment. Gelatin methacrylate and gelatin vanillin hydrogel fibers (GV) were used as nanofiber patches to cover damaged tendons, enabling the sustained release of ibuprofen (ibu) within the local inflammatory microenvironment. In vitro experiments confirmed that the biomimetic "Tendon Band-Aid" (GV@ibu) effectively alle

SUBMITTER: Zhang T 

PROVIDER: S-EPMC12871026 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature