Experience-mediated transcriptional memory correlates with hypoxia resistance in the nervous system of the sea hare <i>Aplysia californica</i>.

ABSTRACT: Current therapeutics for hypoxic/ischemic brain damage can benefit from insights resulting from the study of hypoxia/anoxia-resistant organisms. Hypoxia resistance, however, is not a common feature in mammalian models. Being naturally exposed to hypoxic/anoxic conditions, the sea hare Aplysia californica could become a very useful model for the study of hypoxia resistance. Here, we experimentally exposed two cohorts of A. californica, resulting from crosses of adults with different environmental exposure histories, to daily 6 h pulses of hypoxic water conditions (<1.8 mgO₂/mL) for six consecutive days. The transcriptional response to hypoxia was evaluated in the abdominal and pleural/pedal ganglia through the exposure, during rapid reoxygenation, and after >12 h of

SUBMITTER: Rodriguez-Casariego JA 

PROVIDER: S-EPMC12871377 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature