Feasibility Study of an Indicator of Equivalent Potency of Multiple Anesthetics Normalized by Minimum Alveolar Concentration Derived From Response Surface Models.

ABSTRACT:

Background

Minimum alveolar concentration (MAC) is used as the standard measure of potency for volatile anesthetic agents. However, there is a lack of effective and quantitative indicator of the combined potency of multiple coadministered inhalation and intravenous anesthetics. We hypothesized that an indicator of equivalent potency of multiple anesthetics, normalized by MAC and derived from response surface models as a fraction (abbreviated as eMAC fraction), can reflect the total potency of multiple anesthetics.

Method

Fifty-three patients receiving general anesthesia were enrolled. A random dose combination of propofol and remifentanil was administrated before a tetanic electric stimulus which was used to simulate incision. The vital signals and responses of patients were

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12871423 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature